A BIOMIMETIC AND BIOMECHANICAL APPROACH FOR TISSUE ENGINEERING - Hybrid Nanomaterials and a Piezoelectric Tunable Bending Apparatus for Mechanically Stimulated Osteoblast Cells Growth

"The research develops and tests new hybrid biomimetic materials that work as mechanically stimulating “scaffolds” to promote early regeneration in implanted bone healing phases. A biomometic nanostructured osteoconductive material coated apparatus is presented. Bioinspired approaches to materials and templated growth of hybrid networks using self-assembled hybrid organic-inorganic interfaces is finalized to extend the use of hybrids in the medical field. Combined in vivo, in vitro and computer-aided simulations have been carried out. Such multidisciplinary approach allowed us to explore many novel ideas in modelling, design and fabrication of new nanostructured biomaterials and scaffolds with enhanced functionality and improved interaction with OB cells. In vivo tests of Titanium screw implanted in rabbit tibiae have shown that mechanical stimulation was induced by the presence of bioactive hybrid perimplantar scaffold resulting in a differentiation and development of mesenchymal tissues. In order to investigate the relationship between bone growth and applied mechanical loading (strain), a piezoelectically driven cantilever and a computer-controlled apparatus for "in vitro" tests has been developed and presented.)

Factors affecting chemo-physical and rheological behaviour of Zr44-Ti11-Cu10-Ni10-Be25 metal glassy alloy supercooled liquids

Segregation by selective cold crystallizations and glass transition changes in Zr44-Ti11-Cu10-Ni10-Be25 metal supercooled metastable liquid annealed at different temperatures have been theoretically correlated to melt viscosity modifications. Crystallization behavior has been found to be principally related to the high mobility and smaller Be, Cu and Ni atoms. Multiple exothermal peaks in isothermal DSC annealing’s have been observed in these bulk metal glassy supercooled liquids. A significant increase of the glass transitions temperatures were experimentally measured in cold crystallized samples. Isothermal and temperature scans by Differential Scanning Calorimetry have shown that the three smaller elements present in the alloy (namely Be, Ni and Cu) were involved in recrystallization process in the temperatures interval from glass transition to 470°C. Isothermal annealing’s at temperatures ranging from 400° to 450°C have been considered. Glass transitions and crystallization kinetics in the super-cooled liquid have been measured

GREEN ENERGY TO PROTECTING THE ENVIRONMENT

After 1950, began to appear nuclear fission plants. The fission energy was a necessary evil. In this mode it stretched the oil life, avoiding an energy crisis. Even so, the energy obtained from oil represents about 60% of all energy used. At this rate of use of oil, it will be consumed in about 60 years. Today, the production of energy obtained by nuclear fusion is not yet perfect prepared. But time passes quickly. We must rush to implement of the additional sources of energy already known, but and find new energy sources. Green energy in 2010-2015 managed a spectacular growth worldwide of about 5%. The most difficult obstacle met in worldwide was the inconstant green energy produced

A method for pet mechanical properties enhancement

A method for PET mechanical properties enhancement by reactive blending with HBA/HNA Liquid Crystalline Polymers for in situ highly fibrillar composites preparation is presented. LCP/PET blends were reactively extruded in presence of Pyromellitic Di-Anhydride (PMDA) and then characterized by Differential Scanning Calorimetry, Thermally Stimulated Currents and tensile mechanical properties. Moderate amounts of LCP in the PET (0.5 and 5%) and small amounts of thermo-active and reactive compatibilizer in the blend (0.3%) were found to significantly improve LCP melt dispersion, melts shear transfer and LCP fibril formation and adhesion. An unexpected improvement was probably due to the presence of two distinct phases’ supra-molecular structures involving PET-LCP and PMDA

Mitochondria are naturally micro robots - A review

The mitochondrion is a natural robot (cell) with a length of about one micron. Between organisms (plant, animal or human) with its organs and the atomic and molecular components are positioned based cells, which are building all the necessary organs body. Years ago, medical specialists who are studying organ disease have considered that is caused by impaired organ or related to other organs. For example, it was considered that all nerve diseases have started from stress due to disorder of the hypothalamic-pituitary-adrenal (adrenal glands). Today one knows that psychological stress triggers some metabolic, inflammatory and transcriptional perturbations that ultimately dispose to malady in cellular energetics, involving mitochondrial energy production respiratory stress. Future research on mitochondrial can lead to the elucidation of great issues of life (including the generation of illness, aging and death bodies). The main idea of this paper is that mitochondria are independent cells, flexible, essential for complex life

Biologically structured materials

In this paper bio-tissue mathematical modeling serves as a central repository to interface design, simulation, and tissue fabrication. Finite element computer analyses will be used to study the role of local tissue mechanics on endochondral ossification patterns, skeletal morphology and mandible thickness distributions using single and multi-phase continuum material representations of clinical cases of patients implanted with the traditional protocols. New protocols will be hypothesized for the use of the new biologically techno-structured hybrid materials